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ALT-P7 2018-05-15T15:55:45+00:00

ALT-P7: Breast / Gastric cancer drug with antibody-drug conjugate (ADC)

· Alteogen is using NexMab™ ADC technology to develop ALT-P7, a targeted breast / gastric cancer drug.

· It has been reported that HER2 is overexpressed in 20~25% breast cancer patients and in 10~15% gastric cancer patients. HER2 has been one of the most successful anti-cancer targets, and HER2 -targeting monoclonal antibodies, including Herceptin and Perjeta, and an ADC, Kadcyla, were successfully marketed. ALT-P7 is an anti-HER2 targeting ADC utilizing NexMab™ ADC technology.

· ALT-P7’s payload drugs are site specifically conjugated to the HER2 targeted antibody, whereas Kadcyla has drug payloads conjugated, on a non-site specific manner, to the HER2 targeted antibody. Because of the site-specific conjugation, ALT-P7 can be developed as safer and better alternative anti-cancer drug than Kadcyla. A phase I clinical trial is currently being conducted.

Research Process Pre-clinical Phase 1 Phase 2 Phase 3
ALT-P7 Breast/Gastric Cancer ADC
First-in human Domestic Phase I Clinical Trial in Progress
ALT-P7 Breast/Gastric Cancer ADC
First-in human Domestic Phase I Clinical Trial in Progress
Research
Process
Pre-clinical
Phase 1
Phase 2
Phase 3